How to initiate tissue regeneration by generating mutually exclusive cell states.

Published in: PLoS biology (2023)

A healing wound is made of cells that paused proliferation and secrete mitogenic factors and cells that proliferate to replace those lost to cell death. A new study in PLOS Biology describes how 2 conserved signaling pathways could repress each other to create these mutually exclusive cell states.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
signaling pathway
single cell
cell therapy
stem cells
endoplasmic reticulum stress
oxidative stress
mesenchymal stem cells
bone marrow
wound healing