AD and non-AD mediators of the pathway between the APOE genotype and cognition.

Emma NicholsAdam M BrickmanKaitlin B CasalettoKristen Dams-O'ConnorKristen M GeorgeRaj G KumarPriya PaltaJennifer S RabinClaudia L SatizabalJulie SchneiderJudy PaRenaud La Joie

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Both apolipoprotein E (APOE) ε2 and APOE ε4 effects on late-life cognition are mediated by AD neuropathology. The estimated mediated effects of most measures of AD neuropathology were similar. Non-Alzheimer's disease (AD) neurodegenerative pathologies mediate the effect of ε4 independently from AD. Non-AD vascular pathologies did not mediate the effect of the APOE genotype on cognition. The protective effect of APOE ε2 on cognition was stronger in women.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet
white matter
insulin resistance
polycystic ovary syndrome
pregnant women
multiple sclerosis
skeletal muscle