IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells.
Philipp StarklNicolas GaudenzioThomas MarichalLaurent Lionel ReberRiccardo SibilanoMartin L WatzenboeckFrédéric FontaineAndré C MuellerMindy TsaiSylvia KnappStephen J GalliPublished in: Allergy (2021)
Our results both reveal that IgE sensitization enhances the MC's ability to detoxify BV and also assign efficient toxin-neutralizing activity to MC-derived heparin and proteases. Our study thus highlights the potential importance of IgE, MCs, and particular MC products in defense against BV.