The Burden of Surviving Childhood Medulloblastoma: A Population-Based, Matched Cohort Study in Ontario, Canada.
Hallie ColtinPriscila PequenoNing LiuDerek S TsangSumit GuptaMichael D TaylorEric BouffetPaul C NathanVijay RamsawamiPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Survivors of medulloblastoma have significant long-term medical sequelae, increased all-cause mortality, and are frequently dependent on disability supports. Efforts to reduce the toxicity of current therapy, specifically incorporating molecularly informed risk stratification to spare low- and intermediate-risk survivors the toxicity of treatment, are urgently needed. These findings should prompt a re-evaluation of our current treatment approaches where research focused on late-effect interventions should be prioritized.