Inhibition of Histone Deacetylase Activity Increases Cisplatin Efficacy to Eliminate Metastatic Cells in Pediatric Liver Cancers.

Ruhi Gulati Yasmeen FleifilKatherine JenningsAlexander J BondocGreg TiaoJames GellerLubov TimchenkoNikolai Timchenko

Published in: Cancers (2024)

Our studies demonstrate the synergistic benefits of HDAC inhibition and cisplatin to eliminate metastasis-initiating cells in pediatric liver cancers.

Keyphrases

histone deacetylase
induced apoptosis
cell cycle arrest
squamous cell carcinoma
small cell lung cancer
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell proliferation
pi k akt
drug delivery
childhood cancer