Burkholderia cenocepacia ET12 transmission in adults with cystic fibrosis.
Ana C BlanchardLin TangManal TadrosMatthew MullerTheodore SpilkerValerie J WatersJohn J LiPumaElizabeth TullisPublished in: Thorax (2019)
This report describes transmission of a Burkholderia cenocepacia ET12 strain (ET12-Bc) at the Toronto Adult Cystic Fibrosis (CF) Centre occurring from 2008 to 2017. Epidemiological and genomic data from 11 patients with CF were evaluated. Isolates were analysed using whole genome sequencing (WGS). Epidemiological investigation and WGS analysis suggested nosocomial transmission, despite enhanced infection control precautions. This was associated with subsequent deaths in 10 patients. ET12-Bc positive patients are no longer cared for on the same unit as ET12-Bc negative patients.
Keyphrases
- end stage renal disease
- cystic fibrosis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- chronic obstructive pulmonary disease
- gene expression
- escherichia coli
- machine learning
- electronic health record
- staphylococcus aureus
- copy number
- big data
- air pollution
- lung function
- childhood cancer