Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients.
Ami AokiChiaki IwamuraMasahiro KiuchiKaori TsujiAtsushi SasakiTakahisa HishiyaRui HirasawaKota KokuboSachiko KuriyamaAtsushi OnoderaTadanaga ShimadaTetsutaro NagaokaSatoru IshikawaAkira KojimaHaruki MitoRyota HaseYasunori KasaharaNaohide KuriyamaSukeyuki NakamuraTakashi UrushibaraSatoru KanedaSeiichiro SakaoOsamu NishidaKazuhisa TakahashiMotoko Y KimuraShinichiro MotohashiHidetoshi IgariYuzuru IkeharaHiroshi NakajimaTakuji SuzukiHideki HanaokaTaka-Aki NakadaToshiaki KikuchiToshinori NakayamaKoutaro YokoteKiyoshi HiraharaPublished in: Journal of clinical immunology (2024)
Auto-abs to type I IFN found in COVID-19 patients inhibited IFN signaling in dendritic cells and monocytes by blocking the binding of type I IFN to its receptor. The failure to properly induce production of an antibody to SARS-CoV-2 may be a causative factor of COVID-19 severity.