Increased circulating T follicular helper 13 subset correlates with high IgE levels in pediatric allergic asthma.
Xiao TongChaojiao GuanTuo JiCheng CaoJunfeng JiangMin LiuQin GuoPengcheng ZhouFang GongPublished in: European journal of immunology (2022)
We found an elevation of circulating TFH13 cell subset in asthmatic children and the frequency of TFH13 cells positively correlated with the plasma dust mite-specific IgE levels. These results indicated that TFH13 cell subset may be responsible for the immunopathogenesis of excessive IgE accumulation in children with allergic asthma.
Keyphrases
- allergic rhinitis
- lung function
- single cell
- chronic obstructive pulmonary disease
- young adults
- cell therapy
- induced apoptosis
- dendritic cells
- stem cells
- regulatory t cells
- cell death
- weight gain
- health risk
- risk assessment
- body mass index
- air pollution
- signaling pathway
- atopic dermatitis
- bone marrow
- health risk assessment
- endoplasmic reticulum stress
- drinking water
- weight loss
- pi k akt