Metabolomics implicate eicosanoids in severe functional mitral regurgitation.

Thomas M HofbauerKlaus DistelmaierBesnik MuqakuGeorg SpinkaVeronika SeidlHenrike T ArfstenGerhard HagnSamuel Meier-MenchesPhilipp E BartkoNoemi PavoMatthias HokeSuriya PrausmuellerGregor HeitzingerDietmar PilsIrene M LangChristian HengstenbergMartin P HülsmannChristopher GernerGeorg Goliasch

Published in: ESC heart failure (2022)

We report the up-regulation of various eicosanoids in patients with severe FMR, with 8,9-DiHETrE appearing to predict mortality. Our observations may serve as a nucleus for further investigations into the causes and consequences of metabolic derangements in this important valvular abnormality.

Keyphrases

early onset
atrial fibrillation
mass spectrometry
risk factors
drug induced
aortic valve
type diabetes