Monoclonal Antibody Against Mature Interleukin-18 Ameliorates Colitis in Mice and Improves Epithelial Barrier Function.

Shuji IkegamiKeiko MaedaTakeshi UranoJingxi MuMasanao NakamuraTakeshi YamamuraTsunaki SawadaEri IshikawaKenta YamamotoHisanori MutoAkina OishiTadashi IidaYasuyuki MizutaniTakuya IshikawaNaomi KakushimaKazuhiro FurukawaEizaburo OhnoTakashi HondaMasatoshi IshigamiHiroki Kawashima

Published in: Inflammatory bowel diseases (2023)

Anti-IL-18 neoepitope mAb ameliorates acute and chronic colitis, suggesting that this mAb will be an innovative therapeutic option for IBD.

Keyphrases

monoclonal antibody
ulcerative colitis
liver failure
mouse model
drug induced
respiratory failure
high fat diet induced
type diabetes
aortic dissection
insulin resistance
adipose tissue
wild type