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Reduction in Insulin Uncovers a Novel Effect of VEGFB on Cardiac Substrate Utilization.

Rui ShangChae Syng LeeHualin WangRoger DyerChristophe NollAndré C CarpentierIbrahim SultanKari AlitaloRobert BoushelBahira HusseinBrian Rodrigues
Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Our study highlights the novel role of VEGFB in LPL-derived FA supply and utilization. In diabetes, loss of VEGFB action may contribute toward metabolic inflexibility, lipotoxicity, and development of diabetic cardiomyopathy.
Keyphrases
  • type diabetes
  • glycemic control
  • heart failure
  • cardiovascular disease
  • wound healing
  • insulin resistance
  • adipose tissue