Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs.
Christina A CastellaniRyan J LongchampsJason A SumpterCharles E NewcombJohn A LaneMegan L GroveJan BresslerJennifer A BrodyJames S FloydTraci M BartzKent D TaylorPenglong WangAdrienne TinJosef CoreshJames S PankowMyriam FornageEliseo GuallarBrian O'RourkeNathan PankratzChunyu LiuDaniel LevyNona SotoodehniaEric BoerwinkleDan E ArkingPublished in: Genome medicine (2020)
These results demonstrate that changes in mtDNA-CN influence nDNA methylation at specific loci and result in differential expression of specific genes that may impact human health and disease via altered cell signaling.
Keyphrases
- copy number
- genome wide
- mitochondrial dna
- human health
- dna methylation
- cardiovascular disease
- risk assessment
- cardiovascular events
- climate change
- single cell
- type diabetes
- cell therapy
- stem cells
- single molecule
- squamous cell carcinoma
- circulating tumor
- lymph node metastasis
- coronary artery disease
- transcription factor
- genome wide analysis