Human neural stem cell-derived extracellular vesicles protect against Parkinson's disease pathologies.

Eun Ji LeeYoori ChoiHong J LeeDo Won HwangDong Soo Lee

Published in: Journal of nanobiotechnology (2022)

We report that human NSC-derived EVs show an effective neuroprotective property in an in vitro transwell system and in a PD model. The EVs clearly decreased ROS and pro-inflammatory cytokines. Taken together, these results indicate that NSC-derived EVs could potentially help prevent the neuropathology and progression of PD.

Keyphrases

endothelial cells
stem cells
induced pluripotent stem cells
cell death
oxidative stress
anti inflammatory
subarachnoid hemorrhage