Comparative B cell epitope profiling in Japanese and North American cohorts of MDA5+ dermatomyositis reveals a direct association between immune repertoire and pulmonary mortality.
Koichi YamaguchiPaul PolandLei ZhuSiamak Moghadam-KiaRohit AggarwalToshitaka MaenoAkihiko UchiyamaSei-Ichiro MotegiChester V OddisDana P AschermanPublished in: Rheumatology (Oxford, England) (2024)
Japanese and North American MDA5+ dermatomyositis patients manifest markedly different B cell epitope profiles that are associated with higher prevalence of RP-ILD and worse clinical outcome among Japanese patients.
Keyphrases
- interstitial lung disease
- end stage renal disease
- systemic sclerosis
- risk factors
- breast cancer cells
- chronic kidney disease
- ejection fraction
- disease activity
- pulmonary hypertension
- prognostic factors
- rheumatoid arthritis
- peritoneal dialysis
- type diabetes
- single cell
- monoclonal antibody
- systemic lupus erythematosus
- idiopathic pulmonary fibrosis
- cardiovascular disease
- cell death
- patient reported outcomes
- high throughput sequencing