Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?
José Enrique de la Rubia OrtíJose Luis Platero ArmeroClaudia Emmanuela Sanchis-SanchisSandra Sancho-CastilloAlejandro SalazarJordi Caplliure-LlopisEsther Navarro-IllanaCarlos BarriosJesús Escribá-AlepuzMaría BenllochPublished in: Journal of clinical medicine (2021)
The results of this study seem to point to a possible difference in the peripheral use of glucose between patients with bulbar onset ALS and spinal onset ALS, who appear to have possible insulin resistance. These metabolic differences could explain the lower muscle percentage and lower muscular function in spinal onset ALS patients, although further studies are required.