Metformin produces anxiolytic-like effects in rats by facilitating GABAA receptor trafficking to membrane.

Jun FanDi LiHong-Sheng ChenJian-Geng HuangJun-Feng XuWen-Wen ZhuJian-Guo ChenFang Wang

Published in: British journal of pharmacology (2018)

Metformin increased mIPSCs by up-regulating the membrane insertion of GABAA receptors, via a pathway involving AMPK, FoxO3a, and the GABAA receptor-associated protein. Thus metformin has a potential new use in the treatment of anxiety disorders.

Keyphrases

skeletal muscle
signaling pathway
binding protein
combination therapy
human health
replacement therapy