Clinical significance of neoadjuvant chemotherapy for locally advanced colorectal cancer patients with deficient mismatch repair: possibly residual value in the era of immunotherapy.

Mian ChenJunguo ChenJun HuangHuashan LiuWuteng CaoShuangling LuoZhanzhen LiuHuanxin HuSicong LaiYujie HouLiang KangLiang Huang

Published in: Therapeutic advances in gastroenterology (2023)

In this study, NAC was associated with better tumor downstaging and longer 5-year DFS in LACC patients with dMMR. Consequently, NAC might be an additional treatment choice when it comes to such patients in the future.

Keyphrases

neoadjuvant chemotherapy
transcription factor
end stage renal disease
lymph node
locally advanced
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
squamous cell carcinoma
radiation therapy
combination therapy
rectal cancer
replacement therapy
smoking cessation
patient reported