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Eremantholide C from aerial parts of Lychnophora trichocarpha, as drug candidate: fraction absorbed prediction in humans and BCS permeability class determination.

Tamires Guedes CaldeiraDênia Antunes Saúde-GuimarãesIsabel González-ÁlvarezMarival BermejoJacqueline de Souza
Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2021)
The high permeability, in addition to the low solubility, indicated that eremantholide C is a biologically active substance BCS class II. The pharmacological activities, low toxicity and biopharmaceutics parameters demonstrate that eremantholide C has the necessary requirements for the development of a drug product, to be administered orally, with action on inflammation, hyperuricemia and gout.
Keyphrases
  • oxidative stress
  • uric acid
  • endothelial cells
  • adverse drug
  • drug induced
  • metabolic syndrome
  • emergency department
  • mass spectrometry
  • water soluble
  • tandem mass spectrometry