Challenges in Pharmacokinetic Modelling of [ 18 F]fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer Patients.

Thomas RuytenbergIsabeau A CiggaarInge T A PetersWyanne A NoortmanPetra Dibbets-SchneiderLysanne D A N de MuynckJoeri KuilCornelis D de KroonTom J M MolenaarHendrik J F HelmerhorstLenka M Pereira Arias-BoudaAlexander L VahrmeijerAlbert D WindhorstFloris H P van VeldenKatja N GaarenstroomLioe-Fee de Geus-Oei

Published in: Molecular imaging and biology (2024)

Performing pharmacokinetic analysis in the abdominal pelvic region is very challenging. This brief article describes the challenges and pitfalls in pharmacokinetic analysis of a tracer with high physiological accumulation in the intestines, in case of lesions of limited size in the abdominal pelvic area.

Keyphrases

pet ct
positron emission tomography
rectal cancer
computed tomography
high resolution
drug delivery
pet imaging
photodynamic therapy
fluorescence imaging