Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans.
Dea Siggaard StenbaekMartin Korsbak MadsenBrice OzenneSara KristiansenDaniel BurmesterDavid ErritzøeGitte Moos KnudsenPatrick MacDonald FisherPublished in: Journal of psychopharmacology (Oxford, England) (2020)
This is the first study to investigate how individual brain 5-HT2AR binding predicts subjective effects of a single dose of psilocybin. Our findings reinforce the role of cerebral 5-HT2AR in shaping the temporal and mystical features of the psychedelic experience. Future studies should examine whether individual brain levels of 5-HT2AR have an impact on therapeutic outcomes in clinical studies.