Nicorandil increased the cerebral blood flow via nitric oxide pathway and ATP-sensitive potassium channel opening in mice.

Masakazu KotodaTadahiko IshiyamaKazuha MitsuiSohei HishiyamaTakashi Matsukawa

Published in: Journal of anesthesia (2018)

A clinical dose of nicorandil increases CBF without affecting systemic hemodynamics. The positive effect of nicorandil on CBF is most likely caused via both the nitric oxide pathway and KATP channel opening.

Keyphrases

nitric oxide
cerebral blood flow
nitric oxide synthase
hydrogen peroxide
high fat diet induced
metabolic syndrome
adipose tissue