Memory-related process in physiological status and alzheimer's disease.
Seyedeh Nahid FotuhiMohammad Khalaj-KondoriMohammad Ali Hoseinpour FeiziMahnaz TalebiPublished in: Molecular biology reports (2020)
Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds with synaptic plasticity to process all the developing stages required to successful maturation and functional integration, whereby the memory context is ready to leave the hippocampus toward cortex network through consolidation process, for being installed and run the memory disk forever. However, in Alzheimer's disease, brain deal with subtle deadly progressive loss of synapsis, neuronal dysfunction and ultimately network failure, resulting in memory decay and cognitive decline-concluding that AD destroys memory formation related-pathways.
Keyphrases
- cognitive decline
- working memory
- cerebral ischemia
- mild cognitive impairment
- resting state
- machine learning
- functional connectivity
- oxidative stress
- induced apoptosis
- spinal cord
- spinal cord injury
- cognitive impairment
- signaling pathway
- deep learning
- brain injury
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- cell death
- pi k akt