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New links for meprin β within the protease web.

Vahap CanbayUlrich Auf dem Auf dem Keller
Published in: The FEBS journal (2022)
Proteases are organised in interconnected networks, together forming the protease web whose disturbance can have detrimental consequences for tissue homeostasis and response to environmental insults. Membrane-anchored sheddases are proteases that themselves can be released into the pericellular space by ectodomain shedding. Werny et al. have uncovered unexpected promiscuity in ectodomain shedding of meprin β, a metalloprotease with critical functions in inflammation and fibrosis. These findings suggest new links within complex proteolytic networks like the epidermal protease network with potential implications for skin homeostasis, inflammation and response to injury. Comment on: https://doi.org/10.1111/febs.16586.
Keyphrases
  • oxidative stress
  • wound healing
  • human health
  • risk assessment
  • liver fibrosis
  • network analysis