Tumor Mutational Burden and Genomic Alterations in Chinese Small Cell Lung Cancer Measured by Whole-Exome Sequencing.

Shan Su Jian-Jun Zou Yun-Yun Zeng Wen-Chang CenWei ZhouYan LiuDuo-Hua Su Xian-Lan Zhang Hui-Yi HuangAn LeiZhi-Hao Huang Yun JinLei LiNing SuYa-Lin XieZhen-Gang Zhao Jian-Xiong Liu

Published in: BioMed research international (2019)

TP53 and RB1 inactivations were universally detected in SCLC. The Notch and PI3K/AKT/mTOR signaling pathways were both significantly altered, implying potential actionable targets.

Keyphrases

small cell lung cancer
signaling pathway
cell proliferation
brain metastases
copy number
pi k akt
epithelial mesenchymal transition
human health
risk assessment
gene expression
induced apoptosis