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Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study.

Sobhi M GomhaHyam A AbdelhadyDoaa Z H HassainAboubakr H AbdelmonsefMohamed El-NaggarMahmoud M ElaasserHuda K Mahmoud
Published in: Drug design, development and therapy (2021)
Promising anticancer activity of compounds 9 and 11 compared with cisplatin reference drug suggests that these ligands may contribute as lead compounds in search of new anticancer agents to combat chemo-resistance.
Keyphrases
  • molecular docking
  • molecular dynamics simulations
  • photodynamic therapy
  • squamous cell carcinoma
  • emergency department
  • locally advanced
  • drug delivery
  • combination therapy
  • rectal cancer