Correlation of PD-L1 expression on tumour cells between diagnostic biopsies and surgical specimens of lung cancer in real life with respect to biopsy techniques and neoadjuvant treatment.
Daniela GompelmannK SinnJ BruggerD BernitzkyB MoslehH ProschS GeleffA BlessingA TiefenbacherK HoetzeneckerM IdzkoM A HodaPublished in: Journal of cancer research and clinical oncology (2022)
A statistically significant concordance for PD-L1 expression on tumour cells between biopsies from primary lung tumour and resected specimen was found, but of uncertain clinical accuracy. The use of a cut-off value of ≥ 50% PD-L1 TPS resulted only in a moderate agreement. Therefore, the interpretation of the PD-L1 determined form biopsy specimens status should only be considered with caution for treatment decisionsQuery.