Serum reactivity to citrullinated protein/peptide antigens and left ventricular structure and function in the Multi-Ethnic Study of Atherosclerosis (MESA).
Jan M Hughes-AustinRonit KatzDarcy S MajkaMichael H CriquiWilliam H RobinsonGary S FiresteinW Gregory HundleyJoachim H IxPublished in: PloS one (2023)
Greater number of extremely highly reactive antibodies was associated with lower LVEF, but not with LV mass or incident HF. Thus, serum reactivity to citrullinated protein/peptide antigens was associated with subtle subclinical changes in myocardial contractility, but the significance in relation to clinically apparent HF is uncertain.
Keyphrases
- left ventricular
- cardiovascular disease
- dendritic cells
- protein protein
- heart failure
- amino acid
- binding protein
- acute heart failure
- acute myocardial infarction
- hypertrophic cardiomyopathy
- mitral valve
- immune response
- cardiac resynchronization therapy
- magnetic resonance imaging
- coronary artery disease
- type diabetes
- magnetic resonance
- computed tomography
- acute coronary syndrome
- percutaneous coronary intervention
- aortic stenosis
- transcatheter aortic valve replacement