Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases.

Published in: ACS medicinal chemistry letters (2023)

The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders such as cognitive impairments in Alzheimer's disease, Parkinson's disease, schizophrenia, and L-DOPA-induced dyskinesia as well as inflammation and cough.

Keyphrases

small molecule
bipolar disorder
oxidative stress
cerebrospinal fluid
high glucose
cognitive decline
drug induced
binding protein
replacement therapy
preterm birth
smoking cessation
stress induced