Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling.

Fanghui ChenLe ShengTianci ZhouLi YanReid LovelessHonglin LiYong TengYafei Cai

Published in: Journal of experimental & clinical cancer research : CR (2023)

These findings reveal the potential role of Ufl1 and Ufbp1 as gatekeepers to prevent liver fibrosis and subsequent steatohepatitis and HCC development by inhibiting the mTOR pathway.

Keyphrases

liver fibrosis
signaling pathway
cell proliferation
oxidative stress
genome wide
single cell
liver injury
human health
risk assessment
gene expression
climate change
drug induced