Integrated laser ablation-dropletProbe-mass spectrometry for absolute drug quantitation, metabolite detection, and distribution in tissue.
Vlimos KerteszJohn F CahillBernadeta R SrijantoCharles Patrick CollierMarissa VavrekBingming ChenPublished in: Rapid communications in mass spectrometry : RCM (2022)
This study exemplifies the capabilities of integrated laser ablation-dropletProbe-mass spectrometry (LADP-MS) for high resolution absolute drug quantitation analysis of thin tissue sections. This capability will be valuable for applications needing to quantitatively understand the spatial distribution of small molecules in tissue.
Keyphrases
- mass spectrometry
- high resolution
- liquid chromatography
- high performance liquid chromatography
- gas chromatography
- ms ms
- capillary electrophoresis
- tandem mass spectrometry
- high speed
- multiple sclerosis
- liquid chromatography tandem mass spectrometry
- emergency department
- adverse drug
- label free
- drug induced
- electronic health record