Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.

Allaura S ConeStephanie N HurwitzGloria S LeeXuegang YuanYi ZhouYan LiDavid G Meckes

Published in: BMC molecular and cell biology (2020)

Altogether these findings elucidate a novel mechanism for understanding the intracellular trafficking of APP and CTFβ into secreted extracellular vesicles, and the resultant potential impact on neurotoxicity in the context of Alzheimer's disease amyloidopathy.

Keyphrases

cognitive decline
reactive oxygen species
binding protein
human health
climate change
risk assessment