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Neural stem cell-derived exosomes regulate cell proliferation, migration, and cell death of brain microvascular endothelial cells via the miR-9/Hes1 axis under hypoxia.

Xiaojun DengXiaoyi HuShang WangHui ZhaoYaqin WeiJiaqi FuWen-Hui WuJin-Ming LiuCaicai ZhangLili WangPing Yuan
Published in: Animal models and experimental medicine (2024)
NSC-derived EXOs can promote BMEC proliferation and migration and reduce cell death via the miR-9/Hes1 axis under hypoxic conditions. Therefore, EXO therapeutic strategies could be considered for hypoxia-induced vascular injury.
Keyphrases
  • cell proliferation
  • cell death
  • stem cells
  • endothelial cells
  • long non coding rna
  • cell cycle
  • long noncoding rna
  • cell cycle arrest
  • pi k akt
  • mesenchymal stem cells
  • bone marrow