Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.
Xiaowen MaAllen ChenLuma MeloAna Clemente-SanchezXiaojuan ChaoAli Reza AhmadiBrandon PeifferZhaoli SunHiromi SesakiTiangang LiXiaokun WangWanqing LiuRamon A BatallerHong-Min NiWen-Xing DingPublished in: Hepatology (Baltimore, Md.) (2022)
Alcohol consumption decreases hepatic DRP1 resulting in increased megamitochondria and mitochondrial maladaptation that promotes AH by mitochondria-mediated inflammation and cell injury.