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Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.

Xiaowen MaAllen ChenLuma MeloAna Clemente-SanchezXiaojuan ChaoAli Reza AhmadiBrandon PeifferZhaoli SunHiromi SesakiTiangang LiXiaokun WangWanqing LiuRamon A BatallerHong-Min NiWen-Xing Ding
Published in: Hepatology (Baltimore, Md.) (2022)
Alcohol consumption decreases hepatic DRP1 resulting in increased megamitochondria and mitochondrial maladaptation that promotes AH by mitochondria-mediated inflammation and cell injury.
Keyphrases
  • alcohol consumption
  • oxidative stress
  • single cell
  • cell therapy
  • cell death
  • liver injury
  • stem cells
  • mesenchymal stem cells
  • endoplasmic reticulum