Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.

Xiaowen MaAllen ChenLuma MeloAna Clemente-SanchezXiaojuan ChaoAli Reza AhmadiBrandon PeifferZhaoli SunHiromi SesakiTiangang LiXiaokun WangWanqing LiuRamon A BatallerHong-Min NiWen-Xing Ding

Published in: Hepatology (Baltimore, Md.) (2022)

Alcohol consumption decreases hepatic DRP1 resulting in increased megamitochondria and mitochondrial maladaptation that promotes AH by mitochondria-mediated inflammation and cell injury.

Keyphrases

alcohol consumption
oxidative stress
single cell
cell therapy
cell death
liver injury
stem cells
mesenchymal stem cells
endoplasmic reticulum