Synthesis of the ABC Tricyclic System of Daphnicyclidin A.
Jian Long LiHong Wei ShiQi WangYong Hai ChaiJun YangPublished in: Organic letters (2017)
A substrate-stereocontrolled synthesis of the ABC tricyclic system of daphnicyclidin A is developed. The key reactions include an efficient tandem N-allylation-SN2' reaction to assemble 2,3,4-cis trisubstituent pyrrolidine ring C and two intramolecular Horner-Wadsworth-Emmons reactions to construct cycloheptanone ring A and piperidine ring B.
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