Structural modulation of membrane-intercalating conjugated oligoelectrolytes decouples outer membrane permeabilizing and antimicrobial activities.

Alex S MorelandJakkarin LimwongyutSamuel J HoltonGuillermo C Bazan

Published in: Chemical communications (Cambridge, England) (2023)

We report a series of membrane-intercalating conjugated oligoelectrolytes (MICOEs) to probe how structural features impact bacterial membrane integrity and antibiotic activity. Minimum inhibitory concentrations (MICs) and outer membrane (OM) permeability correlated to different structural parameters suggesting that the antimicrobial mechanism is not related to OM permeabilization. However, lipid order parameters and MICs correlated to the same structural feature suggesting a possible link.

Keyphrases

photodynamic therapy
machine learning
quantum dots
single molecule
neural network