Distinct neural signatures of pulvinar in C9orf72 amyotrophic lateral sclerosis mutation carriers and noncarriers.

Anna NigriMario StanzianoDavide FedeliUmberto ManeraStefania FerraroJean Paul MedinaSara PalermoLaura LequioFederica DenegriFederica AgostaEdoardo Gioele SpinelliMassimo FilippiMarina GrisoliMaria Consuelo ValentiniFilippo De MatteiAntonio CanosaAndrea CalvoAdriano ChiòMaria Grazia BruzzoneCristina Moglia

Published in: European journal of neurology (2024)

Pulvinar volume could be a differential biomarker closely related to the C9orf72 mutation. A pulvinar-cortical circuit dysfunction might play a critical role in disease progression and development, in both the genetic phenotype and ALS wild-type patients.

Keyphrases

amyotrophic lateral sclerosis
wild type
end stage renal disease
ejection fraction
genome wide
newly diagnosed
peritoneal dialysis
prognostic factors
oxidative stress
gene expression
copy number
patient reported outcomes
dna methylation