Exploring biological activities of novel Schiff bases derived from amlodipine and in silico molecular modeling studies.
Anum MasoodMohsin Abbas KhanMashooq A BhatBreena AwanRamsha HanifAsim RazaSaharish KhaliqJavaid AhmedFarhat UllahPublished in: Future medicinal chemistry (2024)
Aim: Calcium channel antagonists are of considerable interest in treating elevated blood pressure and its pathologies. Materials & methods: Schiff base derivatives of amlodipine were produced to check its urease inhibition potentials as well antibacterial and antioxidant activities. Structural illustration along with chemical characterization were achieved by spectral techniques ( 1 H NMR, FTIR, 13 C NMR) and docking studies also performed. Results & conclusion: 3g displayed remarkable anti-hypertensive activity compared with parent drug. 3b, 3f and 3g showed urease inhibition potentials. These compounds can aid as lead for further investigations since they exhibited comparable or superior interactions.
Keyphrases
- blood pressure
- hypertensive patients
- magnetic resonance
- high resolution
- solid state
- case control
- anti inflammatory
- oxidative stress
- heart rate
- optical coherence tomography
- molecular dynamics
- molecular docking
- emergency department
- protein protein
- silver nanoparticles
- blood glucose
- metabolic syndrome
- adipose tissue
- drug induced
- small molecule
- dual energy
- adverse drug
- structure activity relationship