Separation and detection of minimal length glycopeptide neoantigen epitopes centering the GSTA region of MUC1 by liquid chromatography/mass spectrometry.
Dapeng ZhouKaijie XiaoZhixin TianPublished in: Rapid communications in mass spectrometry : RCM (2020)
Our data established the LC/MS/MS identities of a clinically relevant MUC1 glycopeptide neoantigen epitope centering the GSTA motif. A library of short MUC1 glycopeptides centered on the GSTA motif was created, which is a critical step for analysis of such antigen epitopes in real biological samples.
Keyphrases
- liquid chromatography
- mass spectrometry
- high resolution mass spectrometry
- tandem mass spectrometry
- high performance liquid chromatography
- simultaneous determination
- gas chromatography
- capillary electrophoresis
- high resolution
- electronic health record
- solid phase extraction
- big data
- monoclonal antibody
- deep learning
- label free
- quantum dots