Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina.

Mark D AdamsFernando PasteranGerman M TragliaJasmine MartinezFanny HuangChristine LiuJennifer S FernandezCarolina LopezLisandro J GonzalezEzequiel AlbornozAlejandra CorsoAlejandro J VilaRobert A BonomoMaria Soledad Ramirez

Published in: Antimicrobial agents and chemotherapy (2020)

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying bla NDM-1 Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. bla NDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying bla PER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.

Keyphrases

klebsiella pneumoniae
escherichia coli
acinetobacter baumannii
multidrug resistant
drug resistant
gram negative
pseudomonas aeruginosa
copy number
single cell
genome wide
genetic diversity
gene expression
transcription factor
drug induced
high throughput sequencing