Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway.
Yulong TangKai YangQingmei LiuYanyun MaHao ZhuKunhai TangChengchun GengJiangnan XieDachun ZhuoWenyu WuLi JinWenze XiaoJiucun WangQi ZhuJing LiuPublished in: Arthritis research & therapy (2023)
PDGFB stimulates the GRB2/ERK/RUNX2 pathway in ADSCs, promotes osteoblastogenesis of ADSCs, and enhances the extracellular matrix of osteoblasts, which may contribute to pathological bone formation in AS.