Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway.

Yulong TangKai YangQingmei LiuYanyun MaHao ZhuKunhai TangChengchun GengJiangnan XieDachun ZhuoWenyu WuLi JinWenze XiaoJiucun WangQi ZhuJing Liu

Published in: Arthritis research & therapy (2023)

PDGFB stimulates the GRB2/ERK/RUNX2 pathway in ADSCs, promotes osteoblastogenesis of ADSCs, and enhances the extracellular matrix of osteoblasts, which may contribute to pathological bone formation in AS.

Keyphrases

extracellular matrix
ankylosing spondylitis
signaling pathway
transcription factor
cell proliferation
pi k akt
rheumatoid arthritis
disease activity
systemic lupus erythematosus