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Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway.

Yulong TangKai YangQingmei LiuYanyun MaHao ZhuKunhai TangChengchun GengJiangnan XieDachun ZhuoWenyu WuLi JinWenze XiaoJiucun WangQi ZhuJing Liu
Published in: Arthritis research & therapy (2023)
PDGFB stimulates the GRB2/ERK/RUNX2 pathway in ADSCs, promotes osteoblastogenesis of ADSCs, and enhances the extracellular matrix of osteoblasts, which may contribute to pathological bone formation in AS.
Keyphrases
  • extracellular matrix
  • ankylosing spondylitis
  • signaling pathway
  • transcription factor
  • cell proliferation
  • pi k akt
  • rheumatoid arthritis
  • disease activity
  • systemic lupus erythematosus