Gene expression profiling of hypertrophic cardiomyocytes identifies new players in pathological remodelling.
Marta Vigil-GarciaCharlotte J DemkesJoep E C EdingDanielle VersteegHesther de RuiterIlaria PeriniLieneke KooijmanMonika M GladkaFolkert W. AsselbergsAryan VinkMagdalena HarakalovaAlexander BossuToon A B van VeenCornelis J BoogerdEva van RooijPublished in: Cardiovascular research (2022)
Using CM-specific transcriptomic analysis, we identified novel genes induced during pathological hypertrophy that are relevant for human HF, and we show that PFKP is a conserved failure-induced gene that can modulate the CM stress response.