Extracellular Vesicles in Pulmonary Fibrosis Models and Biological Fluids of Interstitial Lung Disease Patients: A Scoping Review.
Miriana d'AlessandroLaura BergantiniElena BargagliSilvia VidalPublished in: Life (Basel, Switzerland) (2021)
Fibroblast-to-mesenchymal differentiation, collagen and extracellular matrix deposition are key mechanisms in the development and progression of IPF. EV-coupled miRNA are important modulators of biological processes in terms of intercellular communication as shown in pulmonary fibrosis models as well as biofluids. The helpfulness of EVs as diagnostic and theranostic markers is worth further investigation. The evolving potential of EVs to translate effective EV-based therapies into clinical practice is of growing interest, due to the urgent need for novel therapeutic strategies for IPF patients.
Keyphrases
- pulmonary fibrosis
- end stage renal disease
- extracellular matrix
- interstitial lung disease
- chronic kidney disease
- idiopathic pulmonary fibrosis
- ejection fraction
- newly diagnosed
- systemic sclerosis
- clinical practice
- stem cells
- peritoneal dialysis
- prognostic factors
- rheumatoid arthritis
- small molecule
- climate change
- photodynamic therapy
- patient reported