Isoforms of IDH in breast carcinoma: IDH2 as a potent prognostic factor associated with proliferation in estrogen-receptor positive cases.

Hiroyuki MinemuraKiyoshi TakagiAi SatoMio YamaguchiChiaki HayashiYasuhiro MikiNarumi Harada-ShojiMinoru MiyashitaHironobu SasanoTakashi Suzuki

Published in: Breast cancer (Tokyo, Japan) (2021)

These results suggest that IDH2 is associated with an aggressive phenotype of breast carcinoma through increasing cell proliferation, different from IDH1 and IDH3α, and immunohistochemical IDH2 status is a potent prognostic factor especially in ER-positive breast cancer patients.

Keyphrases

prognostic factors
low grade
estrogen receptor
wild type
cell proliferation
high grade
signaling pathway
cell cycle
pi k akt