Management of lethal recessive alleles in beef cattle through the use of mate selection software.

Lindsay R UppermanBrian P KinghornMichael D MacNeilAlison Louise Van Eenennaam

Published in: Genetics, selection, evolution : GSE (2019)

Genotyping 100% of the herd was never the most profitable outcome in any scenario; however, genotyping some proportion of the herd, together with segregation analysis to cover ungenotyped animals, maximized overall profit in scenarios with large numbers of loci with LOF alleles. As more LOF alleles are identified, such a mate selection software will likely be required to optimally select and allocate matings to balance the rate of genetic gain, embryonic losses, and inbreeding.

Keyphrases

genome wide
dna methylation
high throughput
climate change
data analysis
copy number
genetic diversity
intellectual disability
gene expression
duchenne muscular dystrophy