Dysfunctional Coupling of Cerebral Blood flow and Susceptibility Value in the Bilateral Hippocampus is Associated with Cognitive Decline in Non-dialysis Patients with Chronic Kidney Disease.

Hao WangXu LiuLijun SongWenbo YangMingan LiQian Chen Han Lv Zhen-Chang WangZhenghan YangWenhu LiuZhen-Chang Wang

Published in: Journal of the American Society of Nephrology : JASN (2023)

Our findings demonstrate a new neuropathological mechanism in patients with CKD, which leads to regional changes in CBF-susceptibility coupling. These changes are related to cognitive decline, providing potential imaging markers for assessing clinical disability and cognitive decline in these patients.

Keyphrases

cognitive decline
end stage renal disease
mild cognitive impairment
chronic kidney disease
cerebral blood flow
peritoneal dialysis
ejection fraction
newly diagnosed
high resolution
room temperature
multiple sclerosis
prognostic factors
case report
patient reported outcomes
climate change
ionic liquid