CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling and clinical value.

Francesca BattaglinYasmine BacaJoshua MillsteinYan YangJoanne XiuHiroyuki AraiJingyuan WangFang-Shu OuFederico InnocentiShannon M MumenthalerPriya JayachandranNatsuko KawanishiAnnika LenzShivani SoniSandra AlgazeWu ZhangTaline KhoukazEvanthia Roussos TorresAndreas SeeberJim P AbrahamEmil LouPhilip A PhilipBenjamin A WeinbergAnthony F ShieldsRichard M GoldbergJohn L MarshallAlan P VenookW Michael KornHeinz-Josef Lenz

Published in: Journal for immunotherapy of cancer (2024)

gene expression and distinct molecular features, gene expression profiles, TME cell infiltration, and treatment benefit in CRC. Targeting the CCR5/CCL5 axis may have clinical applications in selected CRC subgroups and may play a key role in developing and deploying strategies to modulate the immune TME for CRC treatment.

Keyphrases

gene expression
dna methylation
single cell
regulatory t cells
cell therapy
liver fibrosis
liver injury
immune response
mesenchymal stem cells