Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density.
Stephen C GirondaSamuel W CentanniJeffrey L WeinerPublished in: bioRxiv : the preprint server for biology (2024)
An early life psychosocial stress (PSS) exposure increases ethanol consumptionMicroglial inhibition during PSS trends towards reducing ethanol consumptionBinge ethanol consumption increases microglial count and alters cell proximityEarly life PSS alters microglial responsivity to binge ethanol consumptionMicroglial inhibition may prevent microglial innate immune memory formation.
Keyphrases
- early life
- stress induced
- inflammatory response
- neuropathic pain
- lipopolysaccharide induced
- innate immune
- lps induced
- mental health
- adipose tissue
- stem cells
- single cell
- cell therapy
- resting state
- spinal cord
- mesenchymal stem cells
- spinal cord injury
- bone marrow
- blood brain barrier
- functional connectivity
- cerebrospinal fluid