Vitamin D3 Supplementation Alleviates Left Ventricular Dysfunction in a Mouse Model of Diet-Induced Type 2 Diabetes: Potential Involvement of Cardiac Lipotoxicity Modulation.
Clothilde PhilouzeJean-Charles MartinCatherine RivaAlexandra MarziouCatherine DefoortCharlène CouturierThierry BertonJulien AstierBernard JoverNathalie GayrardCyril ReboulSandrine GayrardJean-François LandrierPhilippe ObertPublished in: Cardiovascular drugs and therapy (2021)
This work brought to light the beneficial effects of cholecalciferol supplementation, in secondary prevention, on cardiac remodeling and function in a mouse model of diet-induced type 2 diabetes. Those cardioprotective effects may be, at least in part, attributed to the modulation of myocardial levels of lipotoxic species by vitamin D.
Keyphrases
- left ventricular
- mouse model
- type diabetes
- hypertrophic cardiomyopathy
- acute myocardial infarction
- glycemic control
- cardiac resynchronization therapy
- heart failure
- mitral valve
- aortic stenosis
- left atrial
- cardiovascular disease
- insulin resistance
- oxidative stress
- adipose tissue
- percutaneous coronary intervention
- climate change