Prolonged silent carriage, genomic virulence potential and transmission between staff and patients characterize a neonatal intensive care unit (NICU) outbreak of methicillin-resistant Staphylococcus aureus (MRSA).
Sharline MaderaNicole McNeilPaula Hayakawa SerpaJack KammChristy PakCarolyn CaughellAmy NicholsDavid DynermanLucy M LiEstella Sanchez-GuerreroMaira S PhelpsAngela M DetweilerNorma NeffHelen ReyesSteve A MillerDeborah S YokoeJoseph L DeRisiLynn Ramirez-AvilaCharles R LangelierPublished in: Infection control and hospital epidemiology (2022)
Silent transmission of MRSA between HCP and NICU patients likely contributed to a NICU outbreak involving a virulent MRSA strain. WGS enabled data-driven decision making to inform implementation of infection control policies that mitigated the outbreak. Prospective WGS coupled with epidemiologic analysis can be used to detect transmission events and prompt early implementation of control strategies.
Keyphrases
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- end stage renal disease
- preterm infants
- newly diagnosed
- ejection fraction
- primary care
- decision making
- healthcare
- peritoneal dialysis
- prognostic factors
- escherichia coli
- public health
- pseudomonas aeruginosa
- gene expression
- climate change
- risk assessment
- genome wide
- human health
- data analysis