Methemoglobin-Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy.

Published in: Chembiochem : a European journal of chemical biology (2021)

We describe the synthesis, photophysical properties, and photodynamic activity of a methemoglobin (metHb) wrapped covalently by human serum albumins (HSAs) incorporating protoporphyrin IX (PPIX): a metHb-HSA3 -PPIX2 cluster. The metHb core catalyzes H2 O2 disproportionation to generate O2 in tumor tissue. The HSA3 -PPIX2 shell acts as a photosensitizer for 1 O2 formation. The metHb-HSA3 -PPIX2 cluster acts as a dual functional protein drug for photodynamic therapy.

Keyphrases

photodynamic therapy
fluorescence imaging
protein protein
binding protein
cancer therapy
drug induced
small molecule
drug delivery